Combinative therapeutic approach for better blood sugar level control in alloxan diabetic mice

نویسندگان

  • Shweta Shah
  • Subhash Bodhankar
  • Ramesh Bhonde
  • V. Mohan
چکیده

In the present study the combined therapeutic approach of using an isolated compound from a herb and an oral hypoglycemic drug in alloxan-induced diabetic mice is investigated. Herbal drugs can have beneficial effects in terms of reducing the dosage, side effects and duration of action of synthetic drugs. The results show that combined therapy with 4hydroxyisoleucine and pioglitazone is more beneficial than pioglitazone alone and also more beneficial than the combination of 4 hydroxyisoleucine and glyburide in the treatment of diabetes. (Int J Diabetes Metab 14: 104-105, 2006)

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effect of Lactobacillus delbrueckii on Blood Sugar in Diabetic Mice

Background and Aims: Probiotics are defined as live microorganisms that are beneficial to human health. Probiotics are commonly found in some foods such as dairy products or complementary tablets. A recent research shows that probiotics have a significant role in diabetes type 1 and 2 treatment. Among the variety of lactic acid bacteria, Lactobacillus strains are well known in probiotics for th...

متن کامل

Antihyperglycemic and antihyperlipidemic effects of hydroalcoholic extract of Melissa officinalis (Lemon Balm) in alloxan-induced diabetic rats

Introduction: Diabetes mellitus is a metabolic disorder of the endocrine system leading to increased blood glucose concentration in the patients. As a basic treatment for managing the blood glucose level, insulin or hypoglycemic medications are used but herbal medicines are more favored. The design of this research project was to study the therapeutic effect of hydroalcoholic extract of Melissa...

متن کامل

Disaccharidase activities in small intestinal mucosa of alloxan-diabetic mice.

Increased activities of maltase and sucrase of small intestinal mucosa were found in alloxandiabetic mice. Adrenalectomy did not affect the activities of the enzymes in normal mice, but lowered those of alloxan-diabetic mice as well as blood sugar level. Administration of glucocorticoid raised the enzyme activities in normal mice, non-diabetic adrenalectomized mice and adrenalectomized al1oxan-...

متن کامل

Effects of safflower oil on FBS and lipid profile in alloxan induced diabetic rats and its mechanism

Background & Aim: Diabetes mellitus often has been referred to as a syndrome of disordered metabolism, usually due to a combination of hereditary and environmental causes, resulting in abnormal of high blood sugar levels (hyperglycemia). Nowadays, no-drug treatments (medicinal plants) are novel therapeutic approaches in the treatment of diabetes. Experimental: This study aimed at assessing the...

متن کامل

Effects of ethanolic extract of Syzygium cumini (Linn) seed powder on pancreatic islets of alloxan diabetic rats.

The ethanolic extract of seeds of S. cumini increased body weight and decreased blood sugar level in alloxan diabetic albino rats. Level of significance for decrease in blood sugar after feeding alcoholic extract of S. cumini seeds in various doses was highly significant. The extract feeding showed definite improvement in the histopathology of islets. The most important finding is that the bloo...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2006